Inter-organ Communication in Wound Healing
This project investigates the critical role of hemocyte-mediated inter-organ communication in regulating intestinal homeostasis during wound healing. Using Drosophila melanogaster as a model, we explore the JAK/STAT pathway and the impact of hemocyte-derived cytokines, such as Upd3, on intestinal stem cell behavior. By uncovering the molecular mechanisms underlying reactive oxygen species (ROS) signaling and immune training, this research aims to provide a deeper understanding of tissue repair and immune-epithelial dynamics with implications for human health. Read More
Aquaporins and Immunity
This project examines the role of the aquaporin Prip (CG7777) in hemocyte-mediated immune responses in Drosophila melanogaster. Focusing on Prip's function in transporting reactive oxygen species (ROS) into hemocytes, we investigate how this signaling activates pathways like IMD, Toll, and JAK/STAT, influencing cytokine production and intestinal stem cell behavior during tissue repair. By uncovering the molecular mechanisms linking aquaporin-mediated ROS signaling to immune regulation, this research provides insights into conserved processes of immune-epithelial homeostasis with implications for higher organisms. Read More